Next Generation SMART™

The current generation of SMART drugs report on patient adherence via the breath, but Xhale is developing versions that will report on patient metabolism and therapeutic blood levels of the active pharmaceutical ingredient (API).

A future SMART drug that reported on therapeutic blood levels of the API would allow real-time, onsite therapeutic drug monitoring (TDM). This in turn would provide an opportunity for certain drugs with well established efficacy but which have issues of toxicity which require blood level monitoring.

Future SMART drugs that report via the breath on patient metabolism would provide measures of drug pharmacokinetics that are important to patient safety and to the correct analysis of data in clinical trials.

In addition to working on advances in SMART drugs, Xhale is continuing development of future generations of the monitors that sample the breath and detect the drug and related markers. Future generations of these monitors will be smaller, more portable and more integrated with other electronics the patient carries, increasing the ease of use and convenience of the system.